Journal of Advanced Practice Nursing
Uncategorized

New Candidate Genes For Schizophrenia Identified

2.6k
Shares
 
 

Schizophrenia is a severe psychiatric disease characterized by disorganized behavior, delusions and hallucinations. Sadly, there is no clear understanding of its cause.

Now, in a collaborative study, UCLA and Dutch researchers have identified three new candidate genes for schizophrenia that may contribute to a better understanding of how the disease evolves.

Roel A. Ophoff, an assistant professor with the Center for Neurobehavioral Genetics at the Semel Institute for Neuroscience and Human Behavior at UCLA, and his colleagues examined the genetic makeup of 54 Dutch patients diagnosed with deficit schizophrenia, a particularly severe form of the disease that is both chronic and debilitating.

Specifically, they looked at a number of large but rare deletions and duplications in the genome of the patients, known as copy number variants, or CNVs. Scientists suspect that such missing or duplicated segments of DNA could be responsible for increased susceptibility to a number of diseases. In this study, the researchers showed that three of these rare CNVs interrupted genes associated with brain function.

"These genes were not implicated in schizophrenia before," said Ophoff, who holds a joint appointment at the University of Utrecht in the Netherlands. "So next, we tested these three genes in a large follow-up study of more than 750 general-schizophrenia patients and 700 controls. And what surprised us is that roughly 1 percent of schizophrenia patients harbor these genomic deletions."

Changes in these three genes are rare but seem to dramatically increase the risk of developing schizophrenia, Ophoff said. The identification of these new candidate genes will provide a better insight into the underlying biology of schizophrenia and explain why some individuals are at risk to develop the disease.

"Another important step will be to assess the inheritance patterns of such CNVs," Ophoff said. "Since this is an inherited disease affecting approximately 1 percent of the population, this would be valuable toward establishing the clinical relevance of this important class of genomic variations."

The research was supported by a grant from the National Institute of Mental Health and the Netherlands Organization for Health Research and Development. Other authors included Chiara Sabatti of UCLA and Terry Vrijenhoek, Jacobine E. Buizer-Voskamp, Inge van der Stelt, Eric Strengman, Ad Geurts van Kessel, Han G. Brunner and Joris A. Veltman of the Netherlands, as well as the Netherlands Genetic Risk and Outcome in Psychosis (GROUP) Consortium. The authors report no conflict of interest.

Copyright 2008- American Society of Registered Nurses (ASRN.ORG)-All Rights Reserved



 
2.6k
Shares
 
 
 

Articles in this issue:

Leave a Comment

Please keep in mind that all comments are moderated. Please do not use a spam keyword or a domain as your name, or else it will be deleted. Let's have a personal and meaningful conversation instead. Thanks for your comments!

Image Captcha  

Masthead

Masthead

Editor-in Chief:
Kirsten Nicole

Editorial Staff:
Kirsten Nicole
Stan Kenyon
Robyn Bowman
Kimberly McNabb
Lisa Gordon
Stephanie Robinson

Contributors:
Kirsten Nicole
Stan Kenyon
Liz Di Bernardo
Cris Lobato
Elisa Howard
Susan Cramer